Tag: technews

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Day of the Devs is always one of the biggest highlights of Summer Game Fest and The Game Awards. The showcase places the spotlight firmly on emerging indie games and underground titles, and each event always has at least a few projects that are worth adding to your wishlist. Now, Day of the Devs is shaking things up by becoming an independent non-profit organization.

It started in 2012 as a collaboration between iam8bit and Double Fine, which Microsoft bought in 2019. The restructuring means that Day of the Devs will no longer have a formal affiliation with Microsoft and has more leeway to do its own thing while becoming truly platform agnostic.

The team notes that “we have essentially always run things as a non-profit, but making it official — through a fiscal sponsorship partnership with Legacy Global — it opens us up to better funding opportunities, makes our fundraising efforts more transparent and public and helps our sponsors and audience understand how critical their support truly is.” The organization will use funds raised to cover things like venue fees, equipment, staffing, video production and general operating costs.

A fundraising campaign is now up and running. Supporters will receive perks such as keys for a bunch of killer games from a variety of developers and publishers, VIP tickets for events and physical goods. As Game Developer notes, donations to Day of the Devs now count as tax write offs.

Day of the Devs doesn’t charge developers to highlight their games and it wants to keep things free for event attendees. Next up is an in-person showcase in San Francisco on March 17. Developers can now submit their games for consideration.

Day of the Devs has other events planned throughout March, including one at the San Francisco Museum of Modern Art on March 18 and another at the Game Developers Conference. And of course, the organization will host digital showcases around the time of Summer Game Fest and The Game Awards later this year.

This article originally appeared on Engadget at https://www.engadget.com/indie-game-champion-day-of-the-devs-is-now-an-independent-non-profit-163439253.html?src=rss

We may have an adequate understanding of the human body in that, well, we invented aspirin and sequenced the genome, but researchers still find out new things about the humble homo sapien all of the time. Case in point? Scientists just discovered a previously unknown entity hanging out in the human gut and mouth. The researchers are calling these virus-like structures “obelisks”, due to their presumed microscopic shape.

These entities replicate like viruses, but are much smaller and simpler. Due to the minuscule size, they fall into the “viroid” class, which are typically single-stranded RNAs without a protein shell. However, most viroids are infectious agents that cause disease and it doesn’t look like that’s the case with these lil obelisks, as reported by Live Science.

So why are they inside of us and what do they do? That’s the big question. The discoverers at Stanford University, the University of Toronto and the Technical University of Valencia have some theories. They may influence gene activity within the human microbiome, though they also hang out in the mouth. To that end, they have been found using the common mouth-based bacterium Streptococcus sanguinis as a host. It’s been suggested that these viroids infect various bacteria in both the mouth and gut, though we don’t know why.

Some of the obelisks seem to contain instructions for enzymes required for replication, so they look to be more complex than your average viroid, as indicated by Science. In any event, there has been a “chicken and the egg” debate raging for years over whether viruses evolved from viroids or if viroids actually evolved from viruses, so further study could finally end that argument.

While we don’t exactly know what these obelisk sequences do, scientists have discovered just how prevalent they are in our bodies. These sequences are found in roughly seven percent of human gut bacteria and a whopping 50 percent of mouth bacteria. The gut-based structures also feature a distinctive RNA sequence when compared to the mouth-based obelisks. This diversity has led researchers to proclaim that they “comprise a class of diverse RNAs that have colonized, and gone unnoticed in, human, and global microbiomes.”

“I think this is one more clear indication that we are still exploring the frontiers of this viral universe,” computational biologist Simon Roux of the DOE Joint Genome Institute at Lawrence Berkeley National Laboratory told Science.

“It’s insane,” added Mark Peifer, a cell and developmental biologist at the University of North Carolina at Chapel Hill. “The more we look, the more crazy things we see.”

Speaking of frontier medicine, scientists also recently created custom bacteria to detect cancer cells and biometric implants that detect organ rejection after replacement surgery. The human body may be just about as vast and mysterious as the ocean, or even space, but we’re slowly (ever so slowly) unraveling its puzzles.

This article originally appeared on Engadget at https://www.engadget.com/scientists-discover-weird-virus-like-obelisks-in-the-human-gut-and-mouth-162644669.html?src=rss